Cells ‘feel’ farther with this trick
- New research reveals that normal cells can sense their environment beyond what they are attached to, similar to cancer cells that have an enhanced sense of distance.
- A collective of epithelial cells on the surface of tissue can work together to generate higher forces and “feel” through fibrous collagen up to 100 microns away.
- This collective sensing ability allows normal cells to migrate more effectively, but also enables cancer cells to evade detection and spread freely in soft environments.
- The researchers believe that understanding how this collective sensing works could lead to new targets for cancer therapy, potentially by disrupting the ability of cancer cells to “feel” their way forward.
- Funding for this research came from the National Institutes of Health (NIH) and National Science Foundation, with the goal of furthering our understanding of how cancer moves and developing new treatments.
New research offers a clearer picture of how cells can sense beyond their direct environment.
The story of the princess and the pea evokes an image of a highly sensitive royal young woman so refined, she can sense a pea under a stack of mattresses.
When it comes to human biology, it also takes an abnormal individual to sense far beyond its surroundings, in this case, a cancer cell. Now, researchers also know that normal cells can pull a similar trick by working together.
The new research in the journal PNAS can help further the understanding of how cancer moves and point to potential targets to stop that migration.
Amit Pathak, a professor of mechanical engineering and materials science at the McKelvey School of Engineering at Washington University in St. Louis, explains that “depth mechano-sensing” is how cells sense beyond what they are attached to.
In previous research, he and colleagues discovered that abnormal cells with a “high front-rear polarity” (indicative of migrating cells) can sense the farthest depth, up to 10 microns beyond their adhered environment.
Part of that sensory ability has to do with how the cell deforms the surrounding fibrous collagen to reach out into extracellular matrix (ECM) and “feel” the next layer, whether that’s a hard tumor, soft tissue, or bone just around the bend. The single abnormal cell can “feel” the stiffness of the ECM and set its course based on that input.
The new research shows that a collective of epithelial cells, found on the surface of tissue, can do the same and then some, working together to muster enough force to “feel” through the fibrous collagen the layer as far as 100 microns away.
“Because it’s a collective of cells, they are generating higher forces,” says Pathak, who authored the research along with PhD student Hongsheng Yu.
According to their models, this occurs in two distinct phases of cell clustering and migration. What those clustering cells “feel” will affect migration and dispersal.
The extra sensing power of cancer cells means that they can get out of the tumor environment and evade detection, migrating freely thanks to their enhanced sense of what’s ahead, even in a soft environment. Researchers’ next step will be understanding how that works, and if certain regulators allow for the range.
Those regulators could be potential targets for cancer therapy. If a cancer cell can’t “feel” its way forward, its toxic spread may be put in check.
Funding for this research came from the National Institutes of Health (NIH) and National Science Foundation, Civil, Mechanical, and Manufacturing Innovation.
Source: Washington University in St. Louis
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