Can treating inflammation boost pregnancy chances?
- Researchers found that inflammation in the female reproductive tract can make it difficult to conceive, but replenishing a key hormone called progesterone may help keep inflammation in check.
- Inflammation increases when the body lacks sufficient proteins needed to respond to progesterone, which plays a crucial role in embryo development and fetal growth.
- Treating inflammation has been shown to improve embryo survival rates, allowing more embryos to implant themselves in the uterus and increasing the chances of pregnancy.
- More than 60% of pregnancy losses occur in the first four to six weeks, making it essential to understand the early stages of embryo development to save more pregnancies, especially for women with conditions like pelvic inflammatory disease.
- Future research aims to develop effective, convenient, and non-invasive anti-inflammatory treatments, including a new medication or injection, to target specific inflammatory pathways in the female reproductive tract and improve implantation success.
Inflammation in the female reproductive tract may make it difficult to conceive a child, but replenishing a key hormone could keep inflammation in check, according to new research.
Progesterone—often called the “pregnancy hormone”—plays a crucial role in embryo development, the first stage of fetal growth.
In the new study, researchers found that when the body lacks sufficient proteins needed to respond to progesterone, inflammation increases. However, it remains unclear whether these low protein levels directly cause the inflammation.
“What we do know is that inflammation is bad for embryo development,” says Joy Winuthayanon, an associate professor of obstetrics, gynecology, and women’s health at the University of Missouri School of Medicine and coauthor of the study.
“Embryos are highly sensitive to any stressors in their environment. When we treated the inflammation, more embryos survived long enough to implant themselves in the uterus.”
The good news: These findings could help improve women’s chances of becoming pregnant. More than 60% of pregnancy losses occur in the first four to six weeks, which is often before most patients are aware they are pregnant. Understanding the early stages of the embryo’s development could help save more pregnancies, especially for women with certain conditions such as pelvic inflammatory disease.
“Women with low progesterone or inflammation in the reproductive system typically have more difficulty conceiving and becoming pregnant,” says coauthor Mark Hunter, a gynecologic oncologist at MU Health Care, an associate professor at the School of Medicine, and the director of the Division of Gynecologic Oncology.
“This research presents a potential explanation and opens the door to possible treatments.”
Winuthayanon says future research will focus on developing effective, convenient, and non-invasive anti-inflammatory treatments, which could include a new medication or an injection.
“Currently, we are planning to investigate how targeting specific inflammatory pathways in the female reproductive tract might improve the development of embryos and implantation success,” Winuthayanon says.
The research appears in Science Advances.
Source: University of Missouri
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